Research Articles
Start-Up Cycles for Stable SPR: A Practical Guide to Minimizing Baseline Drift
This guide provides researchers, scientists, and drug development professionals with a comprehensive framework for using start-up cycles to minimize baseline drift in Surface Plasmon Resonance (SPR) experiments.
SPR System Equilibration: A Complete Protocol for Reliable Biomolecular Interaction Data
This article provides a comprehensive guide to Surface Plasmon Resonance (SPR) system equilibration, a critical yet often overlooked step for obtaining reliable, publication-quality binding data.
SPR Running Buffer Mastery: A Complete Guide to Preparation, Degassing, and Troubleshooting for Flawless Data
This comprehensive guide details the critical role of Surface Plasmon Resonance (SPR) running buffer in obtaining reliable, high-quality data.
Temperature Effects on SPR Baseline Stability: A Comprehensive Guide for Reliable Biosensing
Surface Plasmon Resonance (SPR) biosensing is a cornerstone of label-free, real-time interaction analysis in drug discovery and biomedical research.
Refractive Index and SPR Baseline Stability: A Comprehensive Guide for Robust Biosensing
This article provides a thorough examination of the critical role refractive index (RI) plays in determining Surface Plasmon Resonance (SPR) baseline stability, a cornerstone for reliable biosensing in drug development...
Solving SPR Baseline Drift After Buffer Change: A Complete Troubleshooting Guide for Researchers
This article provides a comprehensive guide for researchers and drug development professionals facing Surface Plasmon Resonance (SPR) baseline drift following buffer changes.
Decoding SPR Sensorgrams: A Comprehensive Guide to Shapes, Drift, and Data Integrity for Drug Development
This article provides researchers, scientists, and drug development professionals with a complete framework for interpreting Surface Plasmon Resonance (SPR) sensorgrams.
Why Does My SPR Baseline Drift Upward? A Troubleshooting Guide for Researchers
Upward baseline drift in Surface Plasmon Resonance (SPR) is a common challenge that can compromise kinetic data and affinity measurements.
SPR Artifacts Decoded: A Practical Guide to Differentiating and Correcting Baseline Drift vs. Bulk Effect
This article provides researchers, scientists, and drug development professionals with a comprehensive guide to two of the most common artifacts in Surface Plasmon Resonance (SPR) analysis: baseline drift and the...
Baseline Drift in SPR: A Comprehensive Guide to Causes, Impacts on Kinetic Data, and Mitigation Strategies
Baseline drift in Surface Plasmon Resonance (SPR) is a critical yet often overlooked factor that can significantly compromise the accuracy of kinetic parameters, including association (ka) and dissociation (kd) rate...